In many studies, tumor cells from various tissues including the colon, breast, pancreas, lung, ovary, and prostate displayed a higher percentage of RBM3-positive cells by immunohistochemistry as well as by RT-PCR and Western blotting in comparison to their benign counterparts [4, 12], with different studies reporting various magnitudes of expression up-regulation (from 2.4-fold [14] to 10-fold [12]). Here, RBM3 is linked to neoplasm.