Then, in apopulation-based study, 5,806 subjects were followed up for a mean of 7.8 years, showedthat elevated CRP levels were associated with higher prevalence of pre-existing AF (OR1.8, 95% CI 1.2-2.5, p = 0.002) and higher risk for developing future AF (OR 1.31,95% CI 1.08-1.58, p = 0.005)62. This evidence concerns the gene CRP and atrial fibrillation.