HCV core binds to host tumor suppressor proteins, such as p53, p73 and pRb, modulates the expression of the cyclin dependent inhibitor p21Waf1/Cip1 [14, 15], a major target of p53, and regulates the activities of cyclin/cyclin-dependent kinase complexes involved in cell-cycle control and tumor onset/progression [16]. The gene discussed is RB1; the disease is neoplasm.