Similarly, the PKM2-positivity rates for cholangitis, hyperplasia, and stage I, II, III, and IV disease were 14 % (4/28), 0 % (0/2), 0 % (0/6), 52 % (16/31), 60 % (27/45), and 67 % (4/6), respectively (Fig. 2c). This evidence concerns the gene PKM and cholangitis.