BDKRB1 and allergic contact dermatitis: In allergic contact dermatitis with inflammation, B1R may promote scratching as follows: (1) B1R is up regulated in keratinocytes, (2) keratinocytes can also be seen as a “sensory forefront” of neuronal activation and signaling, (3) subsequently, active B1R in the keratinocytes enhances neural sensitization to indirectly promote chronic itching sensations.