Loss of TNF-α, either through using neutralization antibody of TNF-α blockade or knockout mice of TNF-α, resulted in significantly alleviated tissue injury and elevated function in kidneys after renal ischemia, while the transgenic mice with TNF-α overexpression had more pronounced susceptibility to acute kidney injury induced by I/R than that in mice of wild type [27]. Here, TNF is linked to urogenital neoplasm.