Recently it has been demonstrated that polydatin exerted hepatoprotective effect in rats fed with high-fat diet [45] and regulated glucose and lipid metabolism in diabetic models [46] through upregulating the phosphorylation of Akt in liver, and polydatin also exhibited antitumor activity [47] through downregulating the phosphorylation of Akt in human nasopharyngeal carcinoma CNE cells. The gene discussed is AKT1; the disease is nasopharyngeal carcinoma.