Another European cohort (IMPROVE) based study inclusive of 3,418 individuals, of whom 929 had type 2 diabetes Single Nucleotide Polymorphisms (GC; rs2282679 and rs7041) and 7-dehydrocholesterol reductase/NAD synthetase-1 (DHCR7; rs12785878 and rs3829251), was investigated and found to have negative association with 25(OH)D levels, with differences in association significances between type 2 diabetic and nondiabetic individuals. The gene discussed is DHCR7; the disease is type 2 diabetes mellitus.