TNF and rheumatoid arthritis: Activated macrophages, T-and B-lymphocytes, dendritic cells, and other immunocompetent cells are present in the synovia of patients with RA [1], and these cells are involved in the destruction of bone and cartilage as they produce proinflammatory cytokines like tumor necrosis factor-α (TNFα), interleukin-1 (IL-1), interleukin-6 (IL-6), and also interferon-γ (IFN-γ) [2–4].