KIR3DL1 and AIDS: HIV-1-infected individuals with KIR3DS1 and HLA-B alleles of the HLA-Bw4 family, with an isoleucine at position 80 exhibit a significantly slower progression to AIDS [12], and certain alleles of KIR3DL1 resulting in high surface expression of KIR3DL1 are associated with better control of HIV-1 viremia in individuals with HLA-Bw4 [13].