TERT and hepatocellular carcinoma: To examine whether the rs2853669 variant and −124C > T mutation combination is related to methylation of the TERT promoter containing the site at −245 bp relative to ATG, we quantified TERT promoter methylation levels in the four cases of HCC tumors; with rs2853669 variant alone, with the −124C > T mutation alone, with both the variant and mutation combination, and without neither the variation nor the mutation.