We found that the TERT promoter methylation levels were greater in HCC tumors with the rs2853669 variant and −124C > T mutation combination compared with the HCC tumors without both the variation and mutation (P = 0.0009), the HCC tumors the with rs2853669 variant alone (P = 0.0003), and the HCC tumors with the −124C > T mutation alone (P < 0.0001) (Figure 8C). Here, TERT is linked to hepatocellular carcinoma.