In addition, using The Cancer Genome Atlas (TCGA) data set on Oncomine (https://www.oncomine.org), we found that CHRNA1 and CHRNA9 are both significantly overexpressed in GBM with 1.65 and 2.45 fold increase over normal, respectively (Supplementary Figure S3C, S3D). This evidence concerns the gene CHRNA9 and cancer.