In addition, using The Cancer Genome Atlas (TCGA) data set on Oncomine (https://www.oncomine.org), we found that CHRNA1 and CHRNA9 are both significantly overexpressed in GBM with 1.65 and 2.45 fold increase over normal, respectively (Supplementary Figure S3C, S3D). The gene discussed is CHRNA1; the disease is cancer.