Consistently with this model, analysis of reverse phase protein arrays (RPPA) in the cancer genome atlas (TCGA) database revealed that ovarian carcinomas with BRD4 amplification showed significantly downregulated pMEK and pERK compared with those without BRD4 amplification (Figure 3C; Supplementary Table 3). This evidence concerns the gene EIF2AK3 and ovarian carcinoma.