Consistently with previous data in lung cancer cells, where AvidinOX-anchored bCet and bPan induced a dramatic reduction of EGFR consequent to its massive localization within the lysosomes [6], HCS imaging showed that, upon 30-minute incubation with AvidinOX-anchored bCet or bPan but not bRit, EGFR disappeared in FaDu cells (Figure 2A). The gene discussed is EGFR; the disease is lung cancer.