Although several studies have addressed this relationship, including Zhang et al., [21] Ge et al., [22] Dong et al., [23] Chen et al., [24] He et al., [25] Zhang et al., [26] Li et al., [27] Takako et al. [28] and Ji et al., [29] only some reported a strong association between positive/high Oct-4 and cancer stage. This evidence concerns the gene POU5F1 and cancer.