Overall, the CNA profile confirmed the typical MM plasma cell distribution of numerical abnormalities [24–26], where a gain in odd-numbered chromosomes - characteristic of so-called hyperdiploid myeloma - was one of the most frequent CNAs observed (43 samples, 49%), along with Rb1 CN loss on chr.13q14.2 (detected in 48 patients, 53,9%), CKS1B CN gain on chr.1q32.1 (detected in 28 patients, 31,4%), CDKN2C CN loss on chr.1p32.3 (detected in 10 patients, 11.2%), and TP53 CN loss on chr.17p13.1 (detected in 9 patients, 10,1%). This evidence concerns the gene RB1 and Miyoshi myopathy.