MPL and hematologic disorder: Apart from their functions in MK differentiation, RUNX1, GATA1 and c-MPL as well as other epigenetic factors such as BRD4 found in this study are dysregulated in a broad spectrum of hematological malignancies as well as solid tumors (Baratta et al., 2015; Crawford et al., 2008; Crispino, 2005; Harada et al., 2004; Pikman et al., 2006).