Figure 2C). Mutations on other genes known to be required for transcription termination or pre-mRNA processing were rare and did not segregate specifically in any category (Supplementary file 1B). These data suggest that widespread transcription read-through is a distinctive hallmark of ccRCC and identify SETD2 mutations as a putative contributing factor for this phenotype. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.