In fact, mutations in ccRCC are frequently observed in epigenetic factors such as the chromatin-remodeler PBRM1 and the histone modifying enzymes BAP1 and SETD2, highlighting the central role of epigenetic regulation in this particular cancer (Duns et al., 2010; Varela et al., 2011; Dalgliesh et al., 2010; Creighton et al., 2013). Here, SETD2 is linked to nonpapillary renal cell carcinoma.