SETD2 and nonpapillary renal cell carcinoma: To rule out the contribution of different genetic backgrounds in these cell lines, we interrogated RNA-seq data from: SETD2 knockout (KO) ccRCC cells (Ho et al., 2015); SETD2-depleted human mesenchymal stem (MS) cells (Luco et al., 2010); and embryonic stem (ES) cells from Setd2 KO mice (Zhang et al., 2014).