NR3C2 and major depressive disorder: It has been shown that acute stress regulates miR-124 in amygdala of mice in a negative manner which is inversely correlated with mineralocorticoid receptor expression.71 As with our present study, Cao et al.75 reported upregulation of miR-124 in hippocampus of rats subjected to unpredictable chronic mild stress, another model of depression.