CERS3 and ichthyosis: CERS3 contributes to the fatty acid composition and concentration of ceramides in the epidermis and male germ cells.37, 38 Although an association with schizophrenia has not been previously reported, ceramides are important in embryogenesis.38, 39 A deletion in this gene leads to autosomal recessive congenital skin disorder called ichthyosis.40 The DMR within LY6G5C also lies within a CpG island.