As we observed increased tumor cell proliferation and tumor growth in response to CLND, we decided to evaluate the downstream VEGF-A signalling pathways leading to phosphatidylinositol 3′-kinase (PI3K)/AKT and the Mitogen Activated Protein Kinase (MAPK) activation that are relevant to melanoma growth and survival [28–30]. This evidence concerns the gene VEGFA and melanoma.