To determine whether simultaneous targeting of both JAK/STAT and SYK is relevant in DLBCL, we examined the expression of p-STAT3 (Y705) and p-SYK (Y525/526) on a tissue microarray of 62 DLBCL primary tumors, including 41 germinal center-like (GCB) and 21 non-germinal-center-like (non-GCB) tumors classified using Han's algorithm [30] (Figure 1). Here, SYK is linked to diffuse large B-cell lymphoma.