Phospho-flow assay demonstrated a marked and simultaneous down-regulation of p-STAT3, p-AKT and p-ERK in response to increasing concentrations of cerdulatinib in all six primary DLBCL cells regardless of their subtype designation (Figures 8B, 8C and 8D), but inhibition of the individual protein phosphorylation was highly variable among these primary samples. Here, AKT1 is linked to diffuse large B-cell lymphoma.