SYK and neoplasm: We then showed that cerdulatinib, a potent inhibitor of SYK and JAK, has broad anti-tumor activity as demonstrated by inhibition of 1) cellular metabolic function, 2) cell viability, 3) cell cycling, 4) signal transduction through SYK-PLCγ2-AKT or ERK, and 5) signal transduction through JAK-STAT.