Compared to healthy wild type controls, high-grade PanIN and PDAC lesions were evident in GEMM such as KPC (mutant KrasG12D, tp53R270H) and KPC-Brca1 (mutant KrasG12D, tp53R270H, and Brca1) that resemble the pathology of pancreatic cancer patients (Figure 1). This evidence concerns the gene BRCA1 and pancreatic neoplasm.