TP53 and thymus lymphoma: To determine the molecular mechanisms associated with these observations we transcriptionally profiled radiation-induced thymic lymphomas from rapamycin (n = 11) and vehicle (n = 13) treated Fbxw7+/−p53+/− mice or from vehicle treated p53 single heterozygous (p53+/−) mice (n = 8) (Figure 1A; Supplementary Table S1 for experimental details).