The human tumor suppressor gene FBXW7 encodes an F-box protein, mutated and deleted in cancers from a wide spectrum of human tissues, such as bile duct [1], blood [2–5], bone [6], brain [7, 8], breast [9], colon [10], endometrium [11], stomach [12], lung [13], ovary [14], pancreas [15], and prostate [16]. The gene discussed is FBXW7; the disease is neoplasm.