Interestingly, we observed a very significant overlap between genes that are deregulated in Fbxw7+/−/p53+/− mouse tumors and those that are co-expressed with FBXW7 in colon (66 genes; p = 3.3E-13), breast (36 genes; p = 1.0E-05) and lung cancer (30 genes; p = 9.5E-05), respectively (Figure 4A, 4C, and 4E). This evidence concerns the gene TP53 and lung cancer.