[11, 25, 29] On the other hand, the apolipoprotein-E mimetic peptide, OP449 (previously named COG112), was specifically designed to bind to the SET protein and antagonizes the SET-mediated PP2A inactivation.[24, 26] These two compounds have been tested in several different types of cancers with promising results [11, 24–26, 29]. The gene discussed is PTPA; the disease is cancer.