Further, the risk alleles of candidates located in PRE-3 associate with increased CYP19A1 expression, and ENCODE and other data (Eeckhoute et al. 2006, Lee & Maeda 2012) indicate that the NFIC and ZBTB7A TFs may affect PRE-3 repressor activity in endometrial cancer cells. Here, NFIC is linked to endometrial cancer.