VEGFA and neoplasm: Unlike conventional chemoradiotherapy, on one hand, the ZD6474 as an anti-angiogenic agents can cause cytostatic effects rather than cytotoxic effects, that is, anti-angiogenic treatment impede the tumor growth rather than directly kill the tumor tissue to reduce the tumor volume27, on the other hand, ZD6474 can inhibit VEGF-dependent tumor angiogenesis or vascular survival, resulting in a decrease in MVD and permeability, followed by ischemic changes and necrosis of the tumor28.