INSR and neoplasm: Expression of a constitutive active isoform of Insulin Receptor (inrCA) in Ras/Src-activated cells (inrCA,ras1G12V;csk−/−) was sufficient to promote elevation of Wg levels and tumor growth even in a control diet, establishing an InR-Wg-InR amplification circuit that promotes aggressive tumorigenesis (Figure 1E) (Hirabayashi et al., 2013).