Similarly, over-expression of Wts in Ras/Src-activated cells (ras1G12V;csk−/−,wts) fed HDS or in InR/Ras/Src-activated cells (inrCA,ras1G12V;csk−/−,wts) fed a control diet led to a strong suppression of tumor growth and animal lethality (Figure 1D,G and H). Here, CSK is linked to neoplasm.