Feeding HG-9-91-01, a potent inhibitor of SIKs (Clark et al., 2012), led to suppression of tumor growth and animal lethality in both ras1G12V;csk−/− animals fed HDS and in inrCA,ras1G12V;csk−/− animals fed a control diet (Figure 3F-J). This evidence concerns the gene CSK and neoplasm.