There are also known polymorphisms of the PAR-1 gene that are associated with worse prognosis in lung cancer (PAR-1 -14 Ivs A/A), in pancreatic cancer (PAR-1 -506 Ins/Del) and in gastric cancer (PAR-1-505 Ins/Del) [17, 78, 79]. Here, F2R is linked to familial pancreatic carcinoma.