Interestingly, blocking of TGF-β signaling by the TGF-β receptor inhibitor LY2109761 resulted in downregulation of NRP2 mRNA and protein to levels even lower than those of untreated cells (Fig. 3a–c), suggesting autoregulatory TGF-β loops in respective HCC cells. This evidence concerns the gene NRP2 and hepatocellular carcinoma.