Previous work has shown that the protein FMRP regulates activity of 842 biological targets and suggested that some of these likely underlie the manifestation of autistic features in Fragile X syndrome.30 Our findings show that genes encoding FMRP targets are also enriched in ADHD CNVs, which could help explain why children with Fragile X syndrome show such high rates of ADHD. Here, FMR1 is linked to fragile X syndrome.