Circulating endothelin-1 levels were similar in participants with or without hypertension (women: 2.4 pg/ml, SE: 0.04 vs 2.5 pg/ml, SE: 0.10, p = 0.801; men: 2.3 pg/mL, SE: 0.04 vs 2.3 pg/ml, SE: 0.09, p = 0.434). The gene discussed is EDN1; the disease is hypertensive disorder.