EDN1 and coronary artery disorder: Women showed a strong association between higher circulating levels of endothelin-1 and CHD after adjustment for age (HR = 1.51 CI: 1.1–2.1 p = 0.015), but this association was not significant in men (HR = 0.98, CI 0.8–1.2, p = 0.854) (Table 3).