XPO1 primarily functions as a nuclear export protein whose expression is highly up-regulated in many types of aggressive cancers including glioblastoma [2], ovarian [3], osteosarcoma [4], pancreatic [5], cervical [6], renal [7], metastatic melanoma [8], mantle cell lymphoma [9], acute myeloid leukemia [10], multiple myeloma [11, 12], and leukemia [13] and is the sole transporter of the key TSPs and regulatory proteins p53 [14, 15], p73 [16], p21CIP [17], p27KIP1 [18], FOXO [19], IĸB [20], Rb [21], and BRCA1 [22], as well as >200 other cargoes [23]. The gene discussed is XPO1; the disease is cancer.