Although recent genome-wide association studies (GWAS) of asthma and atopic dermatitis have not supported a genetic association between PHF11 and allergy, it remains possible that there may be an association in selected cohorts of severely affected individuals who show a very early age of onset with highly elevated IgE levels and who are more likely to require treatment by specialist clinicians [8]. This evidence concerns the gene PHF11 and atopic eczema.