Given that the knock-down of PHF11 expression in HaCaT keratinocytes led to an increase in IL-8 expression immediately after poly(I:C) treatment whereas the change in cell number and the cellular distribution of claudin-1 occurred later and were independent of poly(I:C), PHF11 may have several roles in the epithelial response to infection and injury. The gene discussed is PHF11; the disease is infection.