Of the available CE-approved kits, only five detect mutations in both the KRAS and NRAS genes: (1) CRC RAScanTM (SURVEYOR®/WAVE®), (2) CRC RASseqTM (both Transgenomics, Inc.), (3) Therascreen® KRAS and NRAS Pyro® kits (Qiagen), (4) OncoCarta (Agena Bioscience), and (5) cobas® KRAS mutation test (Roche) together with LightMix® kits (TIB MOLBIOL) for the cobas system. This evidence concerns the gene KRAS and colorectal carcinoma.