Targeted DNA sequencing of BCOR exon 15 in a validation cohort of 11 additional CCSKs (Supplementary Table 1) revealed in-frame ITDs in 8 additional tumours (Table 1 and Fig. 1b,d), resulting in an overall mutation frequency of 11/14 (78%), including tumours from 7 of 9 males and 4 of 5 females. The gene discussed is BCOR; the disease is neoplasm.