The RIG-I and MDA5 innate antiviral receptors, encoded by the psoriasis-associated genes DDX58 and IFIH1, respectively, bind to viral double-stranded RNA and promote the release of pro-inflammatory cytokines that have been implicated in psoriatic lesion initiation such as type I IFN, IL-1, IL-6, and IL-29 [19, 21, 41]. Here, IFIH1 is linked to psoriasis.