The most recent large scale DNA analyses implicated, apart from the APOE locus, 19 loci containing common, small-effect, susceptibility variants in over 100 AD candidate disease genes, such as CR1, CLU, PICALM, BIN1, EPHA1, MS4A, CD33, CD2AP and ABCA7 [5–8]. Here, APOE is linked to Alzheimer disease.