Finally, we found a number of genes with more or less known function for which a possible relationship with AD may be obvious, or has been described: For example, upregulation of the heat shock proteins HSPA1, HSPA6 and DNAJB1/Hsp40 reflects increasing cellular CPE stress; the prion protein 2 (PRND) was downregulated. Here, HSPA6 is linked to Alzheimer disease.