In this study, we assessed the frequency, clinicopathologic features, and the prognostic impact of concurrent MYC/BCL6 rearrangements or MYC/BCL6 coexpression in a large cohort of de novo DLBCL patients treated with R-CHOP, in comparison to MYC/BCL2 rearrangements and MYC/BCL2 coexpression. Here, DDIT3 is linked to diffuse large B-cell lymphoma.