In summary, DLBCL patients with concurrent MYC/BCL6 rearrangements are not necessarily associated with an inferior prognosis when treated with R-CHOP therapy, unlike DLBCL patients with concurrent MYC/BCL2 rearrangements, probably due to different pathogenesis and MYC expression levels. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.