We also found a remarkable increase in CD11b+Gr1+ MDSCs (Fig. 2B: n = 6 respectively, P < 0.001) as well as CD11b+F4/80+ TAMs (Fig. 2B: n = 6 respectively, P < 0.001) in Tgfbr1/Pten 2cKO HNSCC. This evidence concerns the gene TGFBR1 and head and neck squamous cell carcinoma.