We also examined the expression of INPP4B in a panel of melanoma cell lines compared with pooled melanocytes of three different lines (HEMa-LP, HEMn-MP and HEMn-DP; pooled normal melanocytes were used to simplify analysis, as these melanocyte lines similarly did not express detectable INPP4B by immunoblotting (Supplementary Figure 1)). The gene discussed is INPP4B; the disease is melanoma.