Our study has for the first time established that XBP1 is an important angiogenic factor to maintain normal cardiac function in the early stage of hypertrophy and deregulation of of mir-214 and miR-30* in the hypertrophic and failing hearts inhibits XBP1 and XBP1-induced angiogenesis results in the transition of hypertrophic hearts into heart failure. This evidence concerns the gene XBP1 and heart failure.