In our present study, we further found that XBP1 regulate VEGF expression in cardiomyocytes, which is in a line with that XBP1 s can bind to two regions on the VEGFA promoter contributes to VEGFA expression in response to ER stress in human cancer cells and mouse embryonic fibroblasts [27, 28, 43]. The gene discussed is VEGFA; the disease is cancer.