EPAS1 and Insulin resistance: A recent study briefly showed that lack of HIF2α in adipocytes enhanced body weight and gonWAT inflammation and promoted insulin resistance (6) without addressing WAT angiogenesis or assessing further metabolic organs apart from the gonWAT, such as the scWAT and the liver, and more importantly without reporting the role of adipocyte HIF2α in BAT, as we have thoroughly done here.