These findings on the role of HIF1β and HIF1α, together with our present findings of reduced VEGF-A levels, endothelial cell numbers, and vascularity of WAT and BAT in obese adipocyte-specific HIF2α-deficient mice, unequivocally underline the primacy of adipocyte HIF2α as the major HIF isoform orchestrating the angiogenic response in the WAT and BAT in obesity. Here, EPAS1 is linked to obesity due to melanocortin 4 receptor deficiency.