A recent report has shown that heterozygous HIF2α+/− mice are prone to insulin resistance and AT inflammation in obesity (17); these authors attributed their findings to the absence of HIF2α from macrophages because clodronate-mediated macrophage depletion improved glucose intolerance in HIF2α+/− mice. This evidence concerns the gene EPAS1 and obesity due to melanocortin 4 receptor deficiency.