MAPT and Cognitive impairment: The presence of aggregated tau is a defining feature of several other neurodegenerative diseases, which include progressive supranuclear palsy [27], frontotemporal dementia related to chromosome 17 [28], argyrophilic grain disease (an age-related disease, caused by degeneration of argyrophilic grains, correlating with NFT deposition and cognitive impairment [29]), senile dementia of the NFT type [30], corticobasal degeneration and Pick’s disease [31].