Subsequently, the same researchers identified two further 2-arylquinoline derivatives, [18F]THK5105 and [18F]THK5117 which have superior binding affinity (Ki = 59.3nM for THK523, 7.8nM for THK5105, and 10.9nM for THK5117) and selectivity for tau in AD brains than [18F]THK523, as well as higher brain uptake and more rapid clearance. Here, MAPT is linked to Alzheimer disease.