However, inconsistent clinical responses have been documented over the years, likely due to differences in patient selection, underlying disorder, indications for granulocyte transfusion, e.g., prevention or treatment of infections, type of granulocyte concentrates, e.g., related vs. HLA-matched unrelated donors, use of G-CSF alone or G-CSF and steroids for donor priming, pre-existing alloimmunization or de novo development of antibodies against granulocytes, availability of donors, and treating physicians’ preference [12]. The gene discussed is CSF3; the disease is infection.