PIK3R5 and familial pancreatic carcinoma: Pathway analysis of its target genes via DAVID [60] showed enrichment (FDR < 5 %) of genes in the Jak-Stat signaling pathway, including several receptors of interleukins (PTPN6, IL22RA1, CREBBP, IL28RA, IL15RA, PIK3R5, STAT3; Table 4) and pancreatic cancer pathways (VEGFC, ACVR1B, PIK3R5, EGF, STAT3; Table 4).