Interestingly, recurrent UBR5-ZNF384 fusion has been shown to be oncogenic in EBV-associated nasopharyngeal subtype of HNSCC [67]; amplification of TERT has been shown to be higher in lung squamous [68], suggesting these alterations as potential squamous specific event, though that warrants detailed systematic assessment. This evidence concerns the gene TERT and head and neck squamous cell carcinoma.