To investigate whether TNF-α SNPs rs1800629, rs361525, and rs1799724 are associated with the age at CRC diagnosis, patients were stratified based on the median age at the time of disease diagnosis as ≤57 (n = 50) and >57 (n = 50) years and the genotype and allele frequencies were compared to the age-matched controls. This evidence concerns the gene TNF and colorectal carcinoma.