In summary, [1] NSCLC CD133+ CSC-like cells were enriched upon radiation, [2] cell survival of NSCLC CD133+ cells after radiation was higher than that of CD133- cells, [3] cell survival of IL-6 expressing NCSLC CD133+ cells (sc) was higher than that of IL-6 knocked-down cells (IL-6si) after radiation [4] IL-6 played a role in protecting NSCLC CD133+ cells from radiation-induced DNA damage and apoptosis. This evidence concerns the gene PROM1 and non-small cell lung carcinoma.