To explore the transcriptional effect of SWI/SNF subunit depletion in the human cell lines, we first assessed the effect of SWI/SNF subunit knockdown on proliferation of MLL-AF9 (THP-1) and MLL-AF4 (MV4-11) driven myeloid leukaemia (Fig 3A). The gene discussed is AFF1; the disease is myeloid leukemia.