MUC5AC and cholangiocarcinoma: The main findings of our study, performed in primary cultures of mucin- and mixed- IHCCA subtypes, indicate that: i) among chemotherapeutics, Gemcitabine and the Gemcitabine-Cisplatin combination were more active in inhibiting cell proliferation in mixed-CCA while Cisplatin or Abraxane were more effective against mucin-CCA, where abraxane was also able to induce apoptosis.