In contrast, in mice treated with NVP-BEZ235 or Abraxane, the tumor volume for CD133+ spheroids remained almost stable (NVP-BEZ235: 790 ± 100 mm3 for mixed-IHCCA and 690 ± 100 mm3 for mucin-IHCCA; Abraxane: 730 ± 86 mm3 for mixed-IHCCA and 790 ± 96 mm3 for mucin-IHCCA, p< 0.05 vs controls). Here, MUC5AC is linked to neoplasm.